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  • Title: Whole genome analysis of non-optimal codon usage in secretory signal sequences of Streptomyces coelicolor.
    Author: Li YD, Li YQ, Chen JS, Dong HJ, Guan WJ, Zhou H.
    Journal: Biosystems; 2006 Sep; 85(3):225-30. PubMed ID: 16644095.
    Abstract:
    Non-optimal (rare) codons have been suggested to reduce translation rate and facilitate secretion in Escherichia coli. In this study, the complete genome analysis of non-optimal codon usage in secretory signal sequences and non-secretory sequences of Streptomyces coelicolor was performed. The result showed that there was a higher proportion of non-optimal codons in secretory signal sequences than in non-secretory sequences. The increased tendency was more obvious when tested with the experimental data of secretory proteins from proteomics analysis. Some non-optimal codons for Arg (AGA, CGU and CGA), Ile (AUA) and Lys (AAA) were significantly over presented in the secretary signal sequences. It may reveal that a balanced non-optimal codon usage was necessary for protein secretion and expression in Streptomyces.
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