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  • Title: Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain.
    Author: Austin T, Gibson AP, Branco G, Yusof RM, Arridge SR, Meek JH, Wyatt JS, Delpy DT, Hebden JC.
    Journal: Neuroimage; 2006 Jul 15; 31(4):1426-33. PubMed ID: 16644237.
    Abstract:
    Optical methods provide a means of monitoring cerebral oxygenation in newborn infants at risk of brain injury. A 32-channel optical imaging system has been developed with the aim of reconstructing three-dimensional images of regional blood volume and oxygenation. Full image data sets were acquired from 14 out of 24 infants studied; successful images have been reconstructed in 8 of these infants. Regional variations in cerebral blood volume and tissue oxygen saturation are present in healthy preterm infants. In an infant with a large unilateral intraventricular haemorrhage, a corresponding region of low oxygen saturation was detected. These results suggest that optical tomography may provide an appropriate technique for investigating regional cerebral haemodynamics and oxygenation at the cotside.
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