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  • Title: Participation of an alpha 2-mediated mechanism in the production of forced swimming-stress induced analgesia in mice.
    Author: Tokuyama S, Takahashi M, Kaneto H.
    Journal: J Pharmacobiodyn; 1991 Jun; 14(6):357-61. PubMed ID: 1664461.
    Abstract:
    In mice, both swimming-stress induced analgesia (SW-SIA) and clonidine (CLO) analgesia were dose dependently antagonized by yohimbine, an alpha 2-adrenoceptor antagonist, but not by naloxone, an opioid mu-antagonist. SW-SIA was potentiated by subanalgesic dose of CLO, and CLO analgesia was enhanced by SW-SIA. Animals tolerant to CLO analgesia were tolerant to SW-SIA, in contrast, CLO analgesia was potentiated in SW-SIA tolerant mice. Thus, SW-SIA and CLO analgesia partially share a common alpha 2-adrenergic-dependent mechanism, for their production.
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