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  • Title: [Participation of central and peripheral mu- and delta opiate receptors in anti-arrhythmia action of enkephalins].
    Author: Maslov LN, Lishmanov IuB.
    Journal: Biull Eksp Biol Med; 1991 Aug; 112(8):124-6. PubMed ID: 1664748.
    Abstract:
    It was found, that injection of delta-receptors agonist dalargin before the occlusion of left anterior coronary artery in rats prevented the decrease of ventricular fibrillation threshold (VFT). An injection of naloxone in dose 0.5 mg/kg (for the blockade of mu-receptors only) had no influence on the VFT. Naloxone in dose 1 mg/kg (for the blockade peripheric mu- and delta-receptors) decreased VFT. An intraventricular infusion of dalargin (10 mkg) induced bradycardia and an increase of VFT. It was assumed that anti-arrhythmic effects of enkephalins in acute myocardial ischemia could be realized by an activation of peripheric delta-receptors and central mu-receptors.
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