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  • Title: Microdialysis measurement of acetylcholine in rat hippocampus during severe insulin-induced hypoglycemia.
    Author: Umegaki H, Yamaguchi Y, Suzuki Y, Iguchi A.
    Journal: Neuro Endocrinol Lett; 2006; 27(1-2):128-32. PubMed ID: 16648788.
    Abstract:
    OBJECTIVE: It has been well acknowledged that hypoglycemia induces cognitive impairment. However, the behavior of hippocampal cholinergic system, which is thought to play a key role in cognition, during hypoglycemia remains to be elucidated. MATERIALS AND METHODS: In this study we conducted a microdialysis using 9 weeks old virgin male Wistar/ST rats to determine the changes of extracelluar acethylcholine and glucose levels in the hippocampus during insulin-induced severe hypoglycemia, and compared the results with those obtained from a microdialysis in the striatum. RESULTS: The extracelluar concentrations of acethylcholine both in the hippocampus and striatum did not change during hypoglycemia. CONCLUSION: The results of the present study may suggest that changes of hippocampal cholinergic release may not be involved in the mechanism of cognitive impairment during hypoglycemia.
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