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  • Title: [Enhancement of potential-dependent inactivation of calcium channels of mollusk neurons by tolbutamide].
    Author: Solntseva EI.
    Journal: Neirofiziologiia; 1991; 23(5):515-9. PubMed ID: 1664912.
    Abstract:
    A two-microelectrode voltage-clamp method was used to measure a potential-dependent Ca-current (ICa) on isolated snail neurons. Tolbutamide (1-5 mmol/l) and H-8 (1-30 mumol/l), inhibitors of kinase A, caused a decrease in the peak amplitude and an acceleration of the ICa decay during a depolarizing step. In the presence of tolbutamide a slow (tau 2) time constant of the ICa decay has grown 2-3 times stronger than fast (tau 1) time constant. Curves of inactivation obtained in double-pulse experiments have shown that after tolbutamide application an inactivation of the ICa enhanced when prepulses were to +30(-)+70 mV. The results suggest that dephosphorylation of Ca(2+)-channels enhances a potential-dependent component of the ICa inactivation.
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