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  • Title: [Cardiac troponin I determination in patients with chronic renal failure].
    Author: Flores LM, Hernández Dominguez JL, Otero A, González Juanatey JR.
    Journal: Nefrologia; 2006; 26(1):107-12. PubMed ID: 16649431.
    Abstract:
    OBJECTIVE: The aim of the study was evaluate cardiac troponin I (cTnI) determination in patients with chronic renal failure (CRF) and compare with creatine kinase-MB isoenzyme (CK-MB and CK-MB/CK). METHODS: We performed a retrospective study on patients with CRF with MDRD (modification of diet in renal disease study group) < 60 mL/min admitted with suspected myocardial injury by history, physical examination and electrocardiography. cTnI measurement was assessed at admission with the ACCESS analyzer (Beckman). RESULTS: Acute myocardial injury (AMI) was diagnosed in 10% (47/467) patients with cTnI determination > 0.05 ng/mL, while the diagnostic was angina in 9% (41/467) and in 81% (379/467) we finded other diagnostics. In the AMI group, 49% had chest discomfort, 43% diabetes and the mortality was 45%, while in the angina group were 41%, 32% and 7%, respectively. The sensitivity for cTnI with cut-off value > 0.5 ng/mL was 70% and specificity 92%. The number of false positives was 31% (20 patients). DISCUSSION: cTnI is the preferred biomarker for myocardial damage in patients with CRF. Other cut-off value could enhance the sensitivity for AMI.
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