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  • Title: Pluronic F127 gel effectively controls the burst release of drug from PLGA microspheres.
    Author: Wang Y, Gao JQ, Chen HL, Zheng CH, Liang WQ.
    Journal: Pharmazie; 2006 Apr; 61(4):367-8. PubMed ID: 16649559.
    Abstract:
    To investigate the controlled release effect of a thermo-sensitive gel, Pluronic F127 (PF127) on microspheres, poly[D,L-lactic-co-glycolic acid] (PLGA) microspheres were coated with Pluronic F127 gel and the in vitro release was evaluated. The results demonstrated that PF127, which gelled at 37 degrees C, inhibited the initial burst release of drug from microspheres effectively.
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