These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A study to determine the effect of tacrolimus on ceramide levels in the stratum corneum of patients with atopic dermatitis.
    Author: Paslin D, Wertz P.
    Journal: Int J Dermatol; 2006 Apr; 45(4):352-6. PubMed ID: 16650156.
    Abstract:
    BACKGROUND: Atopic dermatitis (AD) is characterized both by inflammation and by abnormally low ceramide levels in the stratum corneum. Tacrolimus, effective in the treatment of AD, inhibits transcription and release of inflammatory cytokines operative in AD, but it is unknown if tacrolimus normalizes ceramide levels. METHODS: Stratum corneum ceramides of seven subjects with lesional AD were measured before and after treatment with tacrolimus ointment. RESULTS: Treatment with tacrolimus ointment did not increase the ceramide fractions toward or to normal. CONCLUSION: These findings suggest that tacrolimus ointment is effective in the treatment of atopic dermatitis due to its anti-inflammatory actions rather than to any restorative effect on stratum corneum ceramides.
    [Abstract] [Full Text] [Related] [New Search]