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  • Title: Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma.
    Author: Tomas D, Ulamec M, Hudolin T, Bulimbasić S, Belicza M, Kruslin B.
    Journal: Prostate Cancer Prostatic Dis; 2006; 9(4):414-9. PubMed ID: 16652121.
    Abstract:
    The aim of this study was to analyse relationship between changes of the stroma and expression of tenascin-C (TN-C) and laminin in prostate carcinoma. Tenascin-C immunostaining was increased, and laminin decreased in carcinomas compared with peritumoral tissue and benign prostate hyperplasia (P<0.05). Statistical analysis confirmed connection between stromal changes and TN-C expression in prostate carcinoma (P<0.05). Gleason pattern 3 carcinomas showed more pronounced stromal reaction and TN-C expression compared with Gleason pattern 4 carcinomas (P<0.05). The main cells in prostate cancer stroma are myofibroblasts that are also responsible for tenascin production. Degradation of laminin was not connected with myofibroblastic stromal changes.
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