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  • Title: [Alpha-tocopherol protects beta-adrenoreceptors of the rat brain from damaging effects of phospholipase A2].
    Author: Libe ML, Brusovanik VI, Erin AN.
    Journal: Biull Eksp Biol Med; 1991 Jul; 112(7):60-2. PubMed ID: 1665358.
    Abstract:
    The effect of synaptosomal membrane phospholipid hydrolysis by phospholipase A2 and alpha-tocopherol upon the state of beta-adrenergic receptors has been studied. The damaging action of phospholipase A2 on beta-adrenergic receptors, consisting in the decrease of specific binding of 3H-dihydroalprenolol at the expense of diminishing receptor affinity and Bmax was demonstrated. It was shown, that alpha-tocopherol protects beta-adrenergic receptors from damaging effect of phospholipase A2.
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