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  • Title: Cell mediated immune status in carcinoma breast.
    Author: Mohanty I, Nayak M, Nanda BK.
    Journal: Indian J Pathol Microbiol; 1991 Jan; 34(1):1-6. PubMed ID: 1665479.
    Abstract:
    Thirty six cases of carcinoma breast were subjected to the assessment of CMI status by estimating different T lymphocyte parameters. The mean TPLC, T% and TTC in case of carcinoma were 1955/mm3 blood, 41% and 825/mm3 blood respectively which are evidently depressed than that of controls. This depression is progressive and clinical stage related, the least being in stage I and the most being in stage IV. The infiltrating varieties revealed a significant depression of T lymphocyte values than the non-infiltrating ones. Among the infiltrating types, IDC (T-38.9%) and Muc. Ca (T-29.1%) revealed most significant depression, thereby indicating worst prognosis. Six cases of IDCS, 2 cases of Medullary Ca and a solitary case of comedo Ca revealed a significant lymphocyte infiltration into the tumour cell mass proper. There was a depressed lymphocyte values but of lesser magnitude indicating a better prognosis. 6 cases without metastasis (clinical St. I) showed a lesser degree of depressed CMI than the cases with metastasis.
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