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  • Title: [Tumor necrosis factor in medicinal interferon preparations].
    Author: Kuznetsov VP, Babaiants AA, Frolova IS, Zueva LA, Beliaev DL, Khusainov RM, D'iakonova EV, Vyborov AM, Parfenov VV.
    Journal: Vopr Virusol; 1991; 36(4):300-3. PubMed ID: 1665619.
    Abstract:
    In response to virus induction a culture of donor leukocytes alongside with interferon (IF-alpha) produced a factor of tumor necrosis (TNF). The kinetics of TNF and IF-alpha biosynthesis did not depend on the kind of IF used for priming, was rapid, with maximum production within 7-8 hours. Antibodies to IF-alpha and IF-alpha had no effect on TNF production, while antibody to TNF did not reduce IF-alpha yields. TNF in detectable titres was present in medical preparations of native IF-alpha but was absent in preparations of recombinant IF-alpha and IF-alpha as well as in an injection preparation of IF purified by chemical methods.
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