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  • Title: Alpha1-antitrypsin deficiency and hepatic carcinoma.
    Author: Schleissner LA, Cohen AH.
    Journal: Am Rev Respir Dis; 1975 Jun; 111(6):863-8. PubMed ID: 166582.
    Abstract:
    A patient with homozygous ZZ alpha1-antitrypsin deficiency and severe pulmonary emphysema was discovered to have a mixed hepatocellular and cholangiolar hepatic carcinoma arising in a noncirrhotic liver. Because of the increasing frequency of hepatomas in patients with alpha1-antitrypsin deficiency, it is suggested that a causal relationship may exist.
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