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  • Title: [The formation of the catecholaminergic system of the hypothalamus in rats. Dopamine uptake and release].
    Author: Sapronova AIa, Proshliakova EV, Ugriumov MV.
    Journal: Zh Evol Biokhim Fiziol; 1991; 27(4):453-8. PubMed ID: 1665933.
    Abstract:
    The development of the hypothalamic catecholaminergic (CA) system during ontogenesis in rats has been studied with the isotopic biochemical technique in vitro. It has been demonstrated, that at the 15th fetal day, the CA system was functionally inactive at least in its ability for the uptake and K(+)-stimulated release of catecholamines. Since the 16th fetal day, hypothalamic neuronal elements gained an ability for specific uptake and K(+)-stimulated release of the exogenous radioactively labeled dopamine increased significantly. The specific uptake doubled from the 20th fetal till the 9th postnatal day, whereas K(+)-stimulated release doubled between the 9th 45th postnatal days.
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