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  • Title: [Alternating chemotherapeutic treatment in patients with localized undifferentiated small-cell carcinoma of the lung].
    Author: Navarro M, Mur E, Jolis L, Bellmunt J, Bodi R, Solé LA, Rubio D.
    Journal: Rev Clin Esp; 1991 Oct; 189(5):209-12. PubMed ID: 1666192.
    Abstract:
    The results obtained from 23 patients suffering small cell lung carcinoma limited to the thorax, treated with 4 cycles of cyclophosphamide, adriamycin, vincristine alternating with cisplatin and VP/16, followed by mediastinal and holocranial prophylactic radiotherapy in patients with a complete response (CR) are here presented. An 87% of global responses were obtained with a 64% rate of RC. The average survival rate was 12 months with an 18% of patients alive two years after treatment. The main toxicity was hematologic and neurologic. Even if this alternating regime produces a high response rate, the results are not superior to those obtained with conventional chemotherapy.
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