These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The in vivo inhibition of transport enzyme activities in different organs of rat by chlorpromazine is reversible.
    Author: Adhikary G, Nandy P, Chandra S, Sikdar R, Sen PC.
    Journal: Biochem Int; 1991 Dec; 25(5):951-61. PubMed ID: 1666511.
    Abstract:
    Chlorpromazine, an antipsychotic drug is found to inhibit Na+K(+)-ATPase, Ca(2+)-ATPase and acetylcholinesterase activities in the microsomal membranes of rat in vivo, when the drug is injected for certain periods of time. The inhibition seems to be due to the changes in fatty acid composition of lipid and microviscosity of the membranes. However, once the drug has been withdrawn, the enzyme activities are found to return to the normal level in three to five weeks, suggesting that the drug effect is reversible.
    [Abstract] [Full Text] [Related] [New Search]