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  • Title: Macrocycloadditions leading to conformationally restricted small molecules.
    Author: Looper RE, Pizzirani D, Schreiber SL.
    Journal: Org Lett; 2006 May 11; 8(10):2063-6. PubMed ID: 16671782.
    Abstract:
    [reaction: see text] The Cu(I)-catalyzed cycloaddition of alkynes and azides (click reaction) provides a robust method for the construction of macrocyclic small molecules via an intramolecular macrocycloaddition. A three-subunit system has been used to explore the tolerance of this macrocycloaddition to variations of stereochemistries and substituents.
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