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  • Title: Nonmodulation and essential hypertension.
    Author: Hollenberg NK, Williams GH.
    Journal: Curr Hypertens Rep; 2006 May; 8(2):127-31. PubMed ID: 16672145.
    Abstract:
    Nonmodulation is a process in which there is a disorder in angiotensin-dependent control of the renal circulation and adrenal aldosterone release. The abnormalities are associated with an inability to handle a sodium load and salt-sensitive hypertension. All of the features are corrected by angiotensin-converting enzyme inhibition. A striking family history of hypertension and concordance of responses to angiotensin II in sibling pairs have suggested a familial factor. Genes governing renin substrate (angiotensinogen) production showed gene polymorphisms in nonmodulators. As nonmodulation occurs in approximately 40% of patients with essential hypertension, clearly other genes must contribute.
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