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  • Title: Antitumor organometallics. II. Inhibitory effects of two diphenyl-antimony (III) dithiophosphorus derivatives on in vitro and in vivo Ehrlich ascites tumor.
    Author: Socaciu C, Bara A, Silvestru C, Haiduc I.
    Journal: In Vivo; 1991; 5(4):425-8. PubMed ID: 1667268.
    Abstract:
    (Diphenylphosphinodithioato) diphenylantimony (III), Ph2SbS2PPh2 (1) and (diisopropylphosphorodithioato) diphenylantimony(III), Ph2SbS2P(OPri)2 (2) were tested in vivo in male AKR mice and in vitro against Ehrlich ascites tumor cells. Both compounds exhibited dose-dependent inhibitory effects on in vivo tumor growth and on in vitro cell proliferation, cell viability, respiration and protein synthesis. The activities of some enzymes involved in energetic metabolism (Ca-ATPase, LDH, G6Pase) were exacerbated in vitro. The inhibitory effects could be related to the imbalance between ATP-producing and ATP-consuming processes in Ehrlich ascites tumor cells and also to their cell-cycle specificities.
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