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  • Title: Nanoporous surfaces as harvesting agents for mass spectrometric analysis of peptides in human plasma.
    Author: Gaspari M, Ming-Cheng Cheng M, Terracciano R, Liu X, Nijdam AJ, Vaccari L, di Fabrizio E, Petricoin EF, Liotta LA, Cuda G, Venuta S, Ferrari M.
    Journal: J Proteome Res; 2006 May; 5(5):1261-6. PubMed ID: 16674117.
    Abstract:
    Silica-based nanoporous surfaces have been developed in order to capture low molecular weight peptides from human plasma. Harvested peptides were subjected to mass spectrometric analysis by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) as a means of detecting and assessing the bound molecules. Peptide profiles consisting of about 70 peaks in the range 800-10,000 m/z were generated. The method could allow detection of small peptides at ng/mL concentration levels, either in standard solutions or in plasma. The same molecular cutoff effect was observed for mixtures of standard proteins and peptides incubated with silicon-based nanoporous surfaces.
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