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  • Title: Presynaptic unsilencing: searching for a mechanism.
    Author: Atasoy D, Kavalali ET.
    Journal: Neuron; 2006 May 04; 50(3):345-6. PubMed ID: 16675387.
    Abstract:
    Nascent synaptic networks have a high incidence of silent synapses. In this issue of Neuron, Shen et al. show that a brief burst of action potentials rapidly awaken silent synapses by increasing the availability of synaptic vesicles for fusion through BDNF-triggered presynaptic actin remodeling mediated by the small GTPase Cdc42.
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