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  • Title: Sodium deficient rats are unmotivated by sodium chloride solutions mixed with the sodium channel blocker amiloride.
    Author: McCutcheon NB.
    Journal: Behav Neurosci; 1991 Oct; 105(5):764-6. PubMed ID: 1667733.
    Abstract:
    Rats were made sodium deficient by furosemide injection and then offered 20 min of access to 0.05 M NaCl mixed with the sodium channel blocker amiloride. Compared with a sodium deficient control group that was also offered 0.05 M NaCl, these rats drank very little. A subsequent test conducted in the same manner with 20 min of access to 0.3 M NaCl mixed with amiloride produced similar results. It is concluded that amiloride blocks the neural information required for generating the attractive taste of NaCl to the sodium deficient rat.
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