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  • Title: Sirolimus rescue for tacrolimus-associated post-transplant autoimmune hemolytic anemia.
    Author: Valentini RP, Imam A, Warrier I, Ellis D, Ritchey AK, Ravindranath Y, Shapiro R, Moritz ML.
    Journal: Pediatr Transplant; 2006 May; 10(3):358-61. PubMed ID: 16677361.
    Abstract:
    Autoimmune hemolytic anemia (AIHA) has been reported to occur after renal transplantation, and typically does so in the first few weeks post-transplant. We report on a 3-yr-old child who developed cold AIHA nearly 1 yr after an ABO identical, living donor renal transplant from his mother. Numerous transfusions, pulse steroids, repeat plasma exchange treatments, and IVIG were unsuccessful. Nearly 3 wk into his illness, tacrolimus was changed to cyclosporine, and then to sirolimus, and resulted in a prompt response. He currently has a normal renal function and a normal hemoglobin level on sirolimus monotherapy.
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