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  • Title: High CO2-bicarbonate buffer modifies GABAergic inhibitory effect at the crayfish neuromuscular synapse.
    Author: Golan H, Barkai E, Grossman Y.
    Journal: Brain Res; 1991 Dec 13; 567(1):149-52. PubMed ID: 1667744.
    Abstract:
    gamma-Aminobutyric acid (GABA) activated channels have a considerable permeability to bicarbonate ions (HCO3-), which might alter the efficacy of chloride-dependent synaptic inhibition. Saturation of the bicarbonate-buffered physiologic solution with 15% CO2/85% O2 increased the depolarizing inhibitory postsynaptic potential (IPSP) amplitude in crayfish muscle by 290% due to a shift of +8.33 mV in its reversal potential. Consequently, the normal inhibition exerted by the IPSP on the excitatory postsynaptic potential is reversed to large excitation.
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