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Title: Severe adenovirus pneumonia (AVP) following infliximab infusion for the treatment of Crohn's disease. Author: Ahmad NM, Ahmad KM, Younus F. Journal: J Infect; 2007 Jan; 54(1):e29-32. PubMed ID: 16678268. Abstract: We report a case of severe AVP three weeks following the administration of infliximab for the treatment of Crohn's disease (CD). Since the introduction of tumor necrosis factor-alpha (TNF-alpha) antagonists, various microbiologic agents have been reported to cause pneumonia following their administration. To our knowledge, AVP following therapy with TNF-alpha antagonists has not been reported in English literature. We present a brief review of the mechanism of action of TNF-alpha antagonists and their ability to predispose to various infections including viral pneumonia by interfering with the immune response.[Abstract] [Full Text] [Related] [New Search]