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  • Title: Severe adenovirus pneumonia (AVP) following infliximab infusion for the treatment of Crohn's disease.
    Author: Ahmad NM, Ahmad KM, Younus F.
    Journal: J Infect; 2007 Jan; 54(1):e29-32. PubMed ID: 16678268.
    Abstract:
    We report a case of severe AVP three weeks following the administration of infliximab for the treatment of Crohn's disease (CD). Since the introduction of tumor necrosis factor-alpha (TNF-alpha) antagonists, various microbiologic agents have been reported to cause pneumonia following their administration. To our knowledge, AVP following therapy with TNF-alpha antagonists has not been reported in English literature. We present a brief review of the mechanism of action of TNF-alpha antagonists and their ability to predispose to various infections including viral pneumonia by interfering with the immune response.
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