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  • Title: Survival and major neonatal complications in infants born between 22 0/7 and 24 6/7 weeks of gestation (1999-2003).
    Author: Herber-Jonat S, Schulze A, Kribs A, Roth B, Lindner W, Pohlandt F.
    Journal: Am J Obstet Gynecol; 2006 Jul; 195(1):16-22. PubMed ID: 16678782.
    Abstract:
    OBJECTIVE: This study was undertaken to compare survival and morbidity until discharge in infants born after 22-23 versus 24 weeks' gestational age (GA). STUDY DESIGN: Cohort study of all infants 25 weeks or less, born in 3 tertiary perinatal centers (1999-2003). RESULTS: Of a total of 336 infants, 133 (40%) died before or immediately after birth without the provision of life support, 203 (60%) received active neonatal treatment. Infants with life support (n = 82 at 22 to 23 weeks, n = 121 at 24 weeks) differed with respect to antenatal steroid prophylaxis (44% vs 62%) and cesarean section rate (51% vs 71%). Survival was 67% compared with 82% (P = .016). The incidence of intraventricular hemorrhage III or greater or periventricular leukomalacia (15/15%), severe retinopathy of prematurity (18/15%), and chronic lung disease (40/47%) was similar in both GA groups. CONCLUSIONS: The provision of life support for extremely preterm infants increases their chance of survival without more neonatal morbidity.
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