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  • Title: Functional degradation of extrastriate visual cortex in senescent rhesus monkeys.
    Author: Yu S, Wang Y, Li X, Zhou Y, Leventhal AG.
    Journal: Neuroscience; 2006 Jul 07; 140(3):1023-9. PubMed ID: 16678974.
    Abstract:
    The receptive field properties of striate cortical (V1) cells degrade in senescent macaque monkeys. We have now carried out extracellular single unit studies of the receptive field properties of cells in extrastriate visual cortex (area V2) in very old rhesus (Macaca mulatta) monkeys. This study provides evidence that both the orientation and direction selectivities of V2 cells in old monkeys degrade significantly. Decreased selectivity is accompanied by increased visually driven and spontaneous responses. As a result, V2 cells in old animals exhibit markedly decreased signal-to-noise ratios. A significant degradation of neural function in extrastriate cortex may underlie the declines in higher order visual function that accompany normal aging.
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