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  • Title: Hydrodynamic narrowing of tubes extruded from cells.
    Author: Brochard-Wyart F, Borghi N, Cuvelier D, Nassoy P.
    Journal: Proc Natl Acad Sci U S A; 2006 May 16; 103(20):7660-3. PubMed ID: 16679410.
    Abstract:
    We discuss the pulling force f required to extrude a lipid tube from a living cell as a function of the extrusion velocity L. The main feature is membrane friction on the cytoskeleton. As recently observed for neutrophils, the tether force exhibits a "shear thinning" response over a large range of pulling velocities, which was previously interpreted by assuming viscoelastic flows of the sliding membrane. Here, we propose an alternative explanation based on purely Newtonian flow: The diameter of the tether decreases concomitantly with the increase of the membrane tension in the lipid tube. The pulling force is found to vary as L(1/3), which is consistent with reported experimental data for various types of cells.
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