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  • Title: [Roles of BMP in the development of the central nervous system].
    Author: Fukuda S, Taga T.
    Journal: Clin Calcium; 2006 May; 16(5):781-85. PubMed ID: 16679619.
    Abstract:
    Bone morphogenetic protein (BMP) signaling is involved in astrocytic differentiation of neural precursor cells. In the nuclei, BMP-downstream transcription factors, i.e. Smad proteins, induce expression of astrocyte-specific genes in cooperation with another cytokine signaling, while inhibiting neuronal and oligodendrocytic differentiation-inducing transcription factors. This cross-inhibitory mechanism contributes to exclusive astrocytic differentiation. Crosstalk among cytokine signaling pathways thus is important for the development of the central nervous system.
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