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  • Title: [The prevention of a postinfarct fall in pressure and hyperactivation of the aortic endothelium in the rat by using the antioxidant ionol].
    Author: Meerson FZ, Lapshin AV, Manukhina EB.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1991 Jul; 77(7):48-56. PubMed ID: 1668158.
    Abstract:
    The stress concomitant with experimental myocardial infarction resulted in endothelial hyperactivation of the isolated rat aorta. The hyperactivation was manifested in potentiated inhibition of norepinephrine-induced contractions of vascular smooth muscle, increased endothelium-dependent relaxation and respective drop of systemic blood pressure. Preliminary treatment of animals with synthetic antioxidant ionol prevented the stress-induced endothelial hyperactivation and beneficially affected the postinfarction time course of blood pressure. The data suggest that the endothelial hyperactivation observed in acute myocardial infarction is induced by stress-induced activation of free-radical oxidation which results in a hyperproduction of endothelium-derived relaxing factor (nitric oxide).
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