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  • Title: De novo calcification of liver and nodal metastases in prostate carcinoma.
    Author: Ghosh P, Santosa AC, Lin GY, Downs TM.
    Journal: Prostate Cancer Prostatic Dis; 2006; 9(4):448-51. PubMed ID: 16683012.
    Abstract:
    Prostate cancer has a distinctly recognized pattern of metastases: multifocal and osteoblastic lesions involving the axial skeleton and non-calcified lymph nodes in the pelvic and lumbar aortic groups. Most adenocarcinomas are capable of producing macrocalcification. We report a case of prostate cancer with de novo calcified metastases to the liver and retroperitoneal lymph nodes mimicking the pattern usually seen in mucin-producing adenocarcinomas arising from the gastrointestinal tract. To our knowledge, this is the first such case to be reported in the literature. We propose a multifactorial mechanism that supports dystrophic calcification in this case. The knowledge of atypical presentation of metastatic disease can prevent diagnostic delay and prompt initiation of therapy.
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