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  • Title: Central nervous system binding sites for calcitonin and calcitonin gene-related peptide.
    Author: Sexton PM.
    Journal: Mol Neurobiol; 1991; 5(2-4):251-73. PubMed ID: 1668388.
    Abstract:
    Alternative splicing of the primary RNA transcript of the calcitonin gene leads to the generation of two distinct peptides, calcitonin (CT) and calcitonin gene-related peptide (CGRP). These peptides share only limited sequence homology and generally subserve different biological functions through their own distinct binding sites, which differ in specificity and distribution. Additionally, a binding site with high-affinity binding for both peptides that has a restricted pattern of distribution has been identified. The present article reviews the biochemical and morphological characteristics of centra CT and CGRP binding sites.
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