These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Comparison of anti-RNA properties of normal and ellipticine functionalized alpha and beta-oligonucleotides.
    Author: Lavignon M, Bertrand JR, Porumb H, Rayner B, Imbach JL, Paoletti C, Malvy C.
    Journal: Nucleic Acids Symp Ser; 1991; (24):117-9. PubMed ID: 1668683.
    Abstract:
    RNA is not cleaved as a consequence of the binding of RNase H to the duplex between RNA and a complementary alpha-oligodeoxyribonucleotide (oligo). In consequence targets have been selected which do not a priori require the action of RNase H to inhibit genetic expression. Two models have been used: The Friend Murine Leukemia Virus (F-MuLV) and the synthesis of rabbit beta globin.alpha-oligos trigger specific inhibitions in both systems. The functionalisation in 5' with the intercalating agent 9-NH2-ellipticine renders the oligos resistant to degradation and allows a direct action on cells.
    [Abstract] [Full Text] [Related] [New Search]