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  • Title: In vitro assessment of antimicrobial peptides as potential agents against several oral bacteria.
    Author: Altman H, Steinberg D, Porat Y, Mor A, Fridman D, Friedman M, Bachrach G.
    Journal: J Antimicrob Chemother; 2006 Jul; 58(1):198-201. PubMed ID: 16687459.
    Abstract:
    BACKGROUND: Antimicrobial peptides are components of the innate immunity that play an important role in systemic and oral health. OBJECTIVES: The antibacterial activity of the amphibian-derived K4 -S4(1-15)a antimicrobial peptide was tested against oral pathogens associated with caries and periodontitis and compared with the activities of the human-derived antimicrobial peptides LL-37 and dhvar4a. METHODS: Growth inhibition of planktonic bacteria was tested using standard microdilution assays. Live/Dead staining followed by confocal scanning laser microscopy (CSLM) was used to determine the bactericidal effect of K4 -S4(1-15)a on Streptococcus mutans attached to a glass surface or grown as biofilm. RESULTS: The cariogenic species S. mutans, Streptococcus sobrinus, Lactobacillus paracasei and Actinomyces viscosus were resistant to LL-37 found in the oral cavity. Porphyromonas gingivalis was the species most resistant to the three tested peptides. K4 -S4(1-15)a demonstrated the highest activity against the tested planktonic bacteria. In addition, K4 -S4(1-15)a was bactericidal to surface-attached S. mutans as well as to S. mutans biofilms grown in vitro. However, surface attachment increased S. mutans resistance to the antimicrobial peptide. CONCLUSIONS: Our results support growing evidence suggesting the use of antimicrobial peptides for prevention and treatment of oral disease.
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