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  • Title: Calibration of [123I]iodine-labeled tissue standards for autoradiographic studies.
    Author: Johnson EW, Sybirska E, al-Tikriti M, Innis RB.
    Journal: Int J Rad Appl Instrum A; 1991; 42(12):1199-201. PubMed ID: 1668802.
    Abstract:
    Autoradiographic images can be analyzed with computer-assisted microdensitometry relative to radioactive reference standards to provide quantitative measurements of regional radioactivity concentrations. [123I]Iodine containing sections of brain paste have been calibrated relative to plastic-embedded tritium(3H) and 125Iodine standards. For exposure times of 8, 12 and 24 h, plastic-embedded standards covered a range concentrations of [123I]iodine from 1000 to 100,000 dpm/mg wet weight. Iodine-123 radioactivity was linear with section thickness from 5 to 30 microns. These studies confirmed the feasibility of using commercially available longer-lived reference standards to provide [123I]iodine equivalent values in absolute units of dpm (or microCi) per mg tissue.
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