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  • Title: Topiramate in migraine prophylaxis: data from a pooled analysis and open-label extension study.
    Author: Bussone G, Usai S, D'Amico D.
    Journal: Neurol Sci; 2006 May; 27 Suppl 2():S159-63. PubMed ID: 16688622.
    Abstract:
    Topiramate is approved for the preventive treatment of migraine in several countries based on the results of three large randomised, double-blind studies that showed that this compound was significantly more effective than placebo in migraine prophylaxis. We review the results of two studies: one which pooled data from the three controlled double-blind trials using 100 mg/day of topiramate, and an open-label extension of two of these trials in which patients received different topiramate doses for an eight-month maintenance period. The overall results confirm that topiramate is effective in reducing migraine frequency, and has a satisfactory tolerability profile.
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