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  • Title: [The role of ACTH in the process of complex heparin compound formation in the blood during immobilization stress].
    Author: Kudriashov BA, Shapiro FB, Lomovskaia EG, Liapina LA.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1975 Feb; 61(2):244-50. PubMed ID: 166892.
    Abstract:
    In rats during stress due to 30 min immobilization the total unenzymatic fibrinolytic activity becomes 4 times as high, and its share in the blood plasma total fibrinolytic activity 1.5 times as high. The same stress with ACTH added up increases these values still more: by 2.5 times. ACTH considerably increases formation of the heparin complexes also in absence of the stress. The ACTH effect on the heparin complexes formation is mediated through adrenal stimulation. In 96 hr after adrenalectomy the additional cortical tissue already responds to ACTH administration and, respectively, the stressor effect with ACTH added up entails still greater increase of the unenzymatic fibrinolytic activity than without ACTH.
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