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  • Title: [Polycystic ovary syndrome as expression of 3-beta-hydroxysteroid dehydrogenase deficiency].
    Author: Sapunar J, Triantafilo Y, Arteaga E, Rojas A, Campino C, López JM, Rodríguez JA.
    Journal: Rev Chil Obstet Ginecol; 1991; 56(3):213-6. PubMed ID: 1668983.
    Abstract:
    Late-onset adrenal enzymatic deficiencies are a common cause of hirsutism. They can produce a PCO syndrome-like clinical course, underscoring the multi-causality of this condition. We report a 18 year old woman with secondary amenorrhea and hirsutism, whose serum levels of testosterone and DHEA-S were 175 ng/dl and 7.3 micrograms/ml and the LH/FSH ratio was 5.9. Dexamethasone decreased testosterone and DHEA-S levels, while the ACTH stimulation test increased the 17 hydroxypregnenolone serum concentration and the 17 hydroxypregnenolone/17 hydroxyprogesterone ratio to values considered diagnostic of 3 beta hydroxysteroid dehydrogenase deficiency.
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