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  • Title: Gene polymorphism association studies in dialysis: bone and mineral metabolism.
    Author: Erturk S, DialGene Consortium.
    Journal: Semin Dial; 2006; 19(3):232-7. PubMed ID: 16689975.
    Abstract:
    Abnormalities in bone and mineral metabolism have a significant impact on morbidity and mortality among patients with end-stage renal disease (ESRD). In addition to confounding environmental factors, genetic susceptibility factors may also influence the occurrence and severity of these abnormalities and account for interindividual variability among patients. Indeed, polymorphisms involving genes of the calcium/parathyroid hormone/calcitriol axis have been associated with bone and mineral metabolism abnormalities. This review summarizes studies involving polymorphisms of candidate genes and their effects on the development of complications related to bone and mineral metabolism abnormalities among patients with ESRD.
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