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  • Title: Can statins reduce perioperative morbidity and mortality in patients undergoing non-cardiac vascular surgery?
    Author: Paraskevas KI, Liapis CD, Hamilton G, Mikhailidis DP.
    Journal: Eur J Vasc Endovasc Surg; 2006 Sep; 32(3):286-93. PubMed ID: 16690330.
    Abstract:
    AIMS: To determine whether statins can reduce perioperative morbidity and mortality in patients undergoing non-cardiac vascular surgery. METHODS: A search using Pubmed was performed to identify reports in English. The search terms were: "statins", "perioperative morbidity", "perioperative mortality" and "vascular surgery". We excluded studies dealing with the effect of statins in cardiac surgery. Retrieved articles were manually searched. RESULTS: Current evidence shows that statins decrease perioperative morbidity and mortality in patients undergoing non-cardiac vascular surgery. Any benefit probably occurs soon (within a month) after initiating treatment. CONCLUSIONS: Appropriately designed trials need to confirm the beneficial effect of perioperative statin therapy in various patient categories. The optimal duration and dose of perioperative statin therapy should be defined.
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