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  • Title: POSH, a scaffold protein for JNK signaling, binds to ALG-2 and ALIX in Drosophila.
    Author: Tsuda M, Seong KH, Aigaki T.
    Journal: FEBS Lett; 2006 May 29; 580(13):3296-300. PubMed ID: 16698022.
    Abstract:
    Plenty of SH3s (POSH) functions as a scaffold protein for the Jun N-terminal kinase (JNK) signal transduction pathway, which leads to cell death in mammalian cultured cells and Drosophila. Here, we show that POSH forms a complex with Apoptosis-linked gene-2 (ALG-2) and ALG-2-interacting protein (ALIX/AIP1) in a calcium-dependent manner. Overexpression of ALG-2 or ALIX in developing imaginal eye discs resulted in roughened or melanized eyes, respectively. These phenotypes were enhanced by co-overexpression of POSH. We found that overexpression of either gene could induce ectopic JNK activation, suggesting that POSH/ALG-2/ALIX may function together in the regulation of the JNK pathway.
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