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  • Title: Synthesis and antidepressant-like action of stereoisomers of imidobenzenesulfonylaziridines in mice evaluated in the forced swimming test.
    Author: Duarte FS, Andrade Eda S, Vieira RA, Uieara M, Nunes RJ, de Lima TC.
    Journal: Bioorg Med Chem; 2006 Aug 01; 14(15):5397-401. PubMed ID: 16698270.
    Abstract:
    The present study describes the chemical synthesis and pharmacological evaluation of a new series of eleven compounds stereoisomers of imidobenzenesulfonylaziridines in the forced-swimming test (FST) in mice. The pharmacological results of these compounds show that six of them, given intraperitoneally, reduced the immobility time of mice evaluated in the FST, an antidepressant-like profile of action similar to imipramine, a well-known standard antidepressant drug used for comparison, without compromising the animals' motor performance. The putative antidepressant-like action demonstrated here indicates their viability for the development of new therapeutic options for the treatment of depression.
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