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  • Title: Measurement of aromatisation by a urine technique suitable for the evaluation of aromatase inhibitors in vivo.
    Author: Jacobs S, Lønning PE, Haynes B, Griggs L, Dowsett M.
    Journal: J Enzyme Inhib; 1991; 4(4):315-25. PubMed ID: 1669831.
    Abstract:
    By modification of a recently developed method for separation of radio-labelled urinary oestrogens we were able to separate oestrogen metabolites and measure their isotope ratios in urine following injections of [3H]delta 4-androstenedione and [14C]oestrone. This method provides a useful tool for studying in vivo aromatisation of delta 4-androstenedione into oestrone in breast cancer patients before and during treatment with aromatase inhibitors.
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