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  • Title: Metoclopramide for migraine-associated hiccup.
    Author: Gupta VK.
    Journal: Int J Clin Pract; 2006 May; 60(5):604-5. PubMed ID: 16700863.
    Abstract:
    Persistent hiccup can be a distressing disorder. I present a case of migraine-attack-associated sustained hiccup. Metoclopramide can swiftly control both hiccup and migraine headache. Vasopressin release probably underlies migraine-aborting action of metoclopramide while restoration of oesophageal smooth muscle function involves competitive dopaminergic antagonism and a prominent cholinergic agonist activity. Episodic prolonged hiccup associated with nausea is an unusual presenting feature of migraine.
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