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  • Title: Mechanisms underlying long- and short-range nodal signaling in Zebrafish.
    Author: Jing XH, Zhou SM, Wang WQ, Chen Y.
    Journal: Mech Dev; 2006 May; 123(5):388-94. PubMed ID: 16701984.
    Abstract:
    Precise regulation of the signaling range of secreted molecules is essential for proper pattern formation during development. The Nodal family of TGF-beta proteins has been shown to function as both short- and long-range signals. But the underlying mechanisms remain elusive. In this study, we investigated the regulation of the signaling range of zebrafish Nodal proteins Cyclops and Squint, which are short- and long-range signals, respectively. We show that (1) the stability of Cyclops and Squint correlates with the activity range but increasing the stability of the short-range Cyclops does not increase its signaling range; (2) structural differences in the N-terminus region of the mature peptides of Cyclops and Squint determine their differences in the signaling range and swapping the N-terminus region of the Squint mature ligand into that of Cyclops makes the latter function at a distance.
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