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  • Title: Ramelteon: profile of a new sleep-promoting medication.
    Author: Owen RT.
    Journal: Drugs Today (Barc); 2006 Apr; 42(4):255-63. PubMed ID: 16703122.
    Abstract:
    To date the mainstay of the pharmacological treatment of insomnia has involved the modulation of the gabaminergic system via benzodiazepines or the Z-drugs, zolpidem, zopiclone or zaleplon. A new approach has explored the melatoninergic system, namely activation of MT1 and MT2 receptors in the suprachiasmatic nucleus of the hypothalamus. Ramelteon (TAK-375) is a novel sleep-promoting agent that acts as an agonist at these receptors; its preclinical pharmacology, mode of action, pharmacokinetics, drug interactions, clinical efficacy, and safety and tolerability are reviewed here.
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