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  • Title: Beijing/W genotype Mycobacterium tuberculosis and drug resistance.
    Author: European Concerted Action on New Generation Genetic Markers and Techniques for the Epidemiology and Control of TuberculosisEuropean Concerted Action on New Generation Genetic Markers and Techniques for the Epidemiology and Control of Tuberculosis RIVM, Bilthoven, the Netherlands..
    Journal: Emerg Infect Dis; 2006 May; 12(5):736-43. PubMed ID: 16704829.
    Abstract:
    Beijing/W genotype Mycobacterium tuberculosis is widespread, may be increasing, and may have a predilection for drug resistance. Individual-level data on >29,000 patients from 49 studies in 35 countries were combined to assess the Beijing genotype's prevalence worldwide, trends over time and with age, and associations with drug resistance. We found 4 patterns for Beijing/W genotype tuberculosis (TB): 1) endemic, not associated with drug resistance (high level in most of East Asia, lower level in parts of the United States); 2) epidemic, associated with drug resistance (high level in Cuba, the former Soviet Union, Vietnam, and South Africa, lower level in parts of Western Europe); 3) epidemic but drug sensitive (Malawi, Argentina); and 4) very low level or absent (parts of Europe, Africa). This study confirms that Beijing/W genotype TB is an emerging pathogen in several areas and a predominant endemic strain in others; it is frequently associated with drug resistance.
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