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  • Title: Semisynthesis and biological evaluation of a novel D-seco docetaxel analogue.
    Author: Thoret S, Guéritte F, Guénard D, Dubois J.
    Journal: Org Lett; 2006 May 25; 8(11):2301-4. PubMed ID: 16706511.
    Abstract:
    [reaction: see text] A 4-methyl-5-oxo docetaxel analogue has been prepared starting from 10-deacetylbaccatin III. This new D-seco docetaxel analogue is slightly less potent than docetaxel at microtubule stabilization in vitro and has about 1/1000th the cytotoxicity of docetaxel. The lack of improved activity for this compound compared to other D-modified taxoids confirms that a C-5 oxygen atom is not required for biological activity.
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