These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Highly enantioselective access to primary propargylamines: 4-piperidinone as a convenient protecting group.
    Author: Aschwanden P, Stephenson CR, Carreira EM.
    Journal: Org Lett; 2006 May 25; 8(11):2437-40. PubMed ID: 16706545.
    Abstract:
    [reaction: see text] We report a highly enantioselective, catalytic three-component coupling of aldehydes, alkynes, and 4-piperidone hydrochloride hydrate to afford the corresponding tertiary propargylamines in useful yields. The selective cleavage of the piperidone protecting group using either ammonia/EtOH or a polymer-supported scavenger amine furnishes primary propargylamines.
    [Abstract] [Full Text] [Related] [New Search]